PittsburghV1, France, Analysis, bibRecord, 000028

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Identifieur interne : 000028 ( France/Analysis ); précédent : 000027; suivant : 000029

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Auteurs : Yangchun Xie [États-Unis] ; Shan Zhu [République populaire de Chine] ; Xinxin Song [États-Unis] ; Xiaofang Sun [République populaire de Chine] ; Yong Fan [République populaire de Chine] ; Jinbao Liu [République populaire de Chine] ; Meizuo Zhong [République populaire de Chine] ; Hua Yuan [République populaire de Chine] ; Lin Zhang [États-Unis] ; Timothy R. Billiar [États-Unis] ; Michael T. Lotze [États-Unis] ; Herbert J. Zeh Iii [États-Unis] ; Rui Kang [États-Unis] ; Guido Kroemer [France] ; Daolin Tang [États-Unis]

Source :

Cell Reports [ 2211-1247 ] ; 2017.

RBID : Hal:hal-01581142

Abstract

Ferroptosis is a form of regulated cell death that may facilitate the selective elimination of tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote ferroptosis via a transcription-dependent mechanism. Here, we show that TP53 limits erastin-induced ferroptosis by blocking dipeptidyl-peptidase-4 (DPP4) activity in a transcription-independent manner. Loss of TP53 prevents nuclear accumulation of DPP4 and thus facilitates plasma-membrane-associated DPP4-dependent lipid peroxidation, which finally results in ferroptosis. These findings reveal a direct molecular link between TP53 and DPP4 in the control of lipid metabolism and may provide a precision medicine strategy for the treatment of colorectal cancer by induction of ferroptosis.

Url:

http://hal.upmc.fr/hal-01581142

DOI: 10.1016/j.celrep.2017.07.055

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Hal, to step Checkpoint: 000034
to stream Main, to step Merge: 000032
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to stream Main, to step Exploration: 000033
to stream France, to step Extraction: 000028

Links to Exploration step

Hal:hal-01581142

Le document en format XML

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<tutelle active="#struct-465414" type="direct"><org type="institution" xml:id="struct-465414" status="VALID">          <orgName>Central South University [Changsha]</orgName>
          <date type="start">2016-09-14</date>
          <desc>            <address>              <addrLine> 932 Lushan S Rd, Yuelu, Changsha, Hunan, China</addrLine>
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<country>République populaire de Chine</country>
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</author>
<author><name sortKey="Yuan, Hua" sort="Yuan, Hua" uniqKey="Yuan H" first="Hua" last="Yuan">Hua Yuan</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-440616" status="VALID">          <orgName>Jilin University</orgName>
          <orgName type="acronym">JLU</orgName>
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<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
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          <desc>            <address>              <country key="FR"></country>
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</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Billiar, Timothy R" sort="Billiar, Timothy R" uniqKey="Billiar T" first="Timothy R." last="Billiar">Timothy R. Billiar</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
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          <desc>            <address>              <country key="FR"></country>
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<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Lotze, Michael T" sort="Lotze, Michael T" uniqKey="Lotze M" first="Michael T." last="Lotze">Michael T. Lotze</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
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</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
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</author>
<author><name sortKey="Zeh Iii, Herbert J" sort="Zeh Iii, Herbert J" uniqKey="Zeh Iii H" first="Herbert J." last="Zeh Iii">Herbert J. Zeh Iii</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
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<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
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</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Kang, Rui" sort="Kang, Rui" uniqKey="Kang R" first="Rui" last="Kang">Rui Kang</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
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</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-418262" status="VALID">          <orgName>Plateforme de métabolomique</orgName>
          <desc>            <address>              <addrLine>Gustave Roussy</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
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          <desc>            <address>              <addrLine>Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
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        </org>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Tang, Daolin" sort="Tang, Daolin" uniqKey="Tang D" first="Daolin" last="Tang">Daolin Tang</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.pitt.edu/</ref>
          </desc>
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          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.celrep.2017.07.055</idno>
<series><title level="j">Cell Reports </title>
<idno type="ISSN">2211-1247</idno>
<imprint><date type="datePub">2017</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">Ferroptosis is a form of regulated cell death that may facilitate the selective elimination of tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote ferroptosis via a transcription-dependent mechanism. Here, we show that TP53 limits erastin-induced ferroptosis by blocking dipeptidyl-peptidase-4 (DPP4) activity in a transcription-independent manner. Loss of TP53 prevents nuclear accumulation of DPP4 and thus facilitates plasma-membrane-associated DPP4-dependent lipid peroxidation, which finally results in ferroptosis. These findings reveal a direct molecular link between TP53 and DPP4 in the control of lipid metabolism and may provide a precision medicine strategy for the treatment of colorectal cancer by induction of ferroptosis.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
</region>
<settlement><li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Xie, Yangchun" sort="Xie, Yangchun" uniqKey="Xie Y" first="Yangchun" last="Xie">Yangchun Xie</name>
</region>
<name sortKey="Billiar, Timothy R" sort="Billiar, Timothy R" uniqKey="Billiar T" first="Timothy R." last="Billiar">Timothy R. Billiar</name>
<name sortKey="Kang, Rui" sort="Kang, Rui" uniqKey="Kang R" first="Rui" last="Kang">Rui Kang</name>
<name sortKey="Lotze, Michael T" sort="Lotze, Michael T" uniqKey="Lotze M" first="Michael T." last="Lotze">Michael T. Lotze</name>
<name sortKey="Song, Xinxin" sort="Song, Xinxin" uniqKey="Song X" first="Xinxin" last="Song">Xinxin Song</name>
<name sortKey="Tang, Daolin" sort="Tang, Daolin" uniqKey="Tang D" first="Daolin" last="Tang">Daolin Tang</name>
<name sortKey="Zeh Iii, Herbert J" sort="Zeh Iii, Herbert J" uniqKey="Zeh Iii H" first="Herbert J." last="Zeh Iii">Herbert J. Zeh Iii</name>
<name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Shan" sort="Zhu, Shan" uniqKey="Zhu S" first="Shan" last="Zhu">Shan Zhu</name>
</noRegion>
<name sortKey="Fan, Yong" sort="Fan, Yong" uniqKey="Fan Y" first="Yong" last="Fan">Yong Fan</name>
<name sortKey="Liu, Jinbao" sort="Liu, Jinbao" uniqKey="Liu J" first="Jinbao" last="Liu">Jinbao Liu</name>
<name sortKey="Sun, Xiaofang" sort="Sun, Xiaofang" uniqKey="Sun X" first="Xiaofang" last="Sun">Xiaofang Sun</name>
<name sortKey="Yuan, Hua" sort="Yuan, Hua" uniqKey="Yuan H" first="Hua" last="Yuan">Hua Yuan</name>
<name sortKey="Zhong, Meizuo" sort="Zhong, Meizuo" uniqKey="Zhong M" first="Meizuo" last="Zhong">Meizuo Zhong</name>
</country>
<country name="France"><noRegion><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

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